abstract：CONTEXT:There is increasing interest in ensuring that physicians demonstrate the full range of Accreditation Council for Graduate Medical Education competencies. OBJECTIVE:To determine whether it is possible to develop a feasible and reliable multisource feedback instrument for pathologists and laboratory medicine phy...

journal_title：Archives of pathology & laboratory medicine

authors： Lockyer JM,Violato C,Fidler H,Alakija P

更新日期：2009-08-01 00:00:00

abstract：CONTEXT:Recent studies have uncovered a number of possible mechanisms by which prostate cancers can become resistant to systemic androgen deprivation, most involving androgen-independent reactivation of the androgen receptor. Genome-wide expression analysis with microarrays has identified a wide array of genes that are...

journal_title：Archives of pathology & laboratory medicine

authors： Mackinnon AC,Yan BC,Joseph LJ,Al-Ahmadie HA

更新日期：2009-07-01 00:00:00

abstract：:Frozen section is a prominent point of intersection between surgeons and pathologists. It is regarded as the most definitive--but not the sole--form of intraoperative consultation. Its role in tissue triage, diagnosis, and intraoperative management should not be misconstrued as a shortcut to a definitive diagnosis. Al...

journal_title：Archives of pathology & laboratory medicine

authors： Taxy JB

更新日期：2009-07-01 00:00:00

abstract：CONTEXT:More than 25 years ago, John G. Azzopardi described a distinctive intraepithelial neoplastic breast lesion, which he designated "clinging carcinoma in situ"; he considered it as another variant of ductal carcinoma in situ, an early lesion that can easily be missed because the changes are mainly cytologic rather...

journal_title：Archives of pathology & laboratory medicine

authors： Moinfar F

更新日期：2009-06-01 00:00:00

abstract：CONTEXT:Correction factors have been proposed for estimating true potassium concentrations in blood samples with evidence of in vitro hemolysis. OBJECTIVE:We used 2 different models of true (ie, nonsimulated) in vitro hemolysis to evaluate the clinical utility of correction factors for estimating potassium concentrati...

journal_title：Archives of pathology & laboratory medicine

authors： Mansour MM,Azzazy HM,Kazmierczak SC

更新日期：2009-06-01 00:00:00

abstract：CONTEXT:The complexities of diagnostic hematopathology in the modern era are well known, and even in this molecular era, immunophenotypic studies, together with routine histopathology, remain a critical component in the evaluation of many lymphoid proliferations. With numerous antibodies that can be used on routinely f...

journal_title：Archives of pathology & laboratory medicine

authors： Garcia CF,Swerdlow SH

更新日期：2009-05-01 00:00:00

abstract：:Epithelioid sarcomas are rare, mesenchymal tumors of unknown histogenesis and display multidirectional differentiation, which is predominantly epithelial. They have no normal cellular counterpart and differ from both synovial sarcoma and carcinoma. They account for less than 1% of all soft tissue sarcomas and are usua...

journal_title：Archives of pathology & laboratory medicine

authors： Armah HB,Parwani AV

更新日期：2009-05-01 00:00:00

abstract：CONTEXT:The pancreas gives rise to an array of distinct neoplasms that can be solid, cystic, or intraductal and can recapitulate the various lines of differentiation present in the normal gland. OBJECTIVE:To develop an algorithmic approach to the diagnosis of pancreatic neoplasms that simplifies their pathologic evalu...

journal_title：Archives of pathology & laboratory medicine

authors： Klimstra DS,Pitman MB,Hruban RH

更新日期：2009-03-01 00:00:00

abstract：CONTEXT:Because the consequences of making an interpretive error on a proficiency test are more severe than those made on an educational challenge, the same slide may exhibit different performance characteristics in the 2 different settings. OBJECTIVE:The results of the 2006 College of American Pathologists Gynecologi...

journal_title：Archives of pathology & laboratory medicine

authors： Hughes JH,Bentz JS,Fatheree L,Souers RJ,Wilbur DC,Cytopathology Resource Committee, College of American Pathologists.

更新日期：2009-02-01 00:00:00

abstract：CONTEXT:In Thailand until 2005 there had been no external quality assessment scheme at the national level for blood coagulation tests. Only a few laboratories had an external quality assessment for these tests. In the year 2005, the Thailand National External Quality Assessment Scheme for Blood Coagulation was founded....

journal_title：Archives of pathology & laboratory medicine

authors： Tientadakul P,Opartkiattikul N,Wongtiraporn W

更新日期：2009-01-01 00:00:00

abstract：CONTEXT:Blood loss from laboratory testing (BLLT) can be significant in hospitalized patients. It is a common practice to draw full large-volume tubes of blood from adults. OBJECTIVE:To determine whether BLLT occurred when a small-volume (pediatric) blood collection tube (SVT) was substituted for each large-volume blo...

journal_title：Archives of pathology & laboratory medicine

authors： Sanchez-Giron F,Alvarez-Mora F

更新日期：2008-12-01 00:00:00

abstract：CONTEXT:Increased thymidylate synthase expression is a marker for decreased survival in colorectal cancer. OBJECTIVE:Thymidylate synthase localizes to both the nucleus and cytoplasm, but how the relationship of these expression levels affects colon cancer outcome has yet to be determined. DESIGN:Using AQUA, we assess...

journal_title：Archives of pathology & laboratory medicine

authors： Gustavson MD,Molinaro AM,Tedeschi G,Camp RL,Rimm DL

更新日期：2008-11-01 00:00:00

abstract：CONTEXT:5-Lipoxygenase (5-LO) is an arachidonic acid- metabolizing enzyme, which has been demonstrated to exert a role in colorectal cancer tumorigenesis. Its activity in promoting neoangiogenesis in colorectal malignancies has been also recently theorized on the basis of in vitro studies. OBJECTIVE:To investigate whe...

journal_title：Archives of pathology & laboratory medicine

authors： Barresi V,Vitarelli E,Tuccari G,Barresi G

更新日期：2008-11-01 00:00:00

abstract：CONTEXT:The development of targeted therapies creates a need to accurately classify tumors. Among the more pressing needs are the identification of the complete catalog of genes that are altered in cancer and the accurate discrimination of tumors based on their genetic background. OBJECTIVES:To discuss the use of gene...

journal_title：Archives of pathology & laboratory medicine

authors： Sanchez-Cespedes M

更新日期：2008-10-01 00:00:00

abstract：CONTEXT:Accurate specimen identification is critical for quality patient care. Improperly identified specimens can result in delayed diagnosis, additional laboratory testing, treatment of the wrong patient for the wrong disease, and severe transfusion reactions. Specimen identification errors have been reported to occu...

journal_title：Archives of pathology & laboratory medicine

authors： Wagar EA,Stankovic AK,Raab S,Nakhleh RE,Walsh MK

更新日期：2008-10-01 00:00:00

abstract：:Hepatic angiomyolipoma is a rare, benign, hepatic mesenchymal neoplasm found in both males and females, and most commonly in adult females. Angiomyolipoma occurs most commonly in the kidneys. The liver represents the second most frequent site of involvement. Hepatic angiomyolipomas are composed of varying amounts of s...

journal_title：Archives of pathology & laboratory medicine

authors： Petrolla AA,Xin W

更新日期：2008-10-01 00:00:00

abstract：CONTEXT:Obesity is associated with sleep disordered breathing and cardiovascular morbidity, but the relationship between pulmonary hypertension, heart disease, and obesity is unknown. OBJECTIVE:To determine the prevalence of pulmonary and cardiovascular disease in obese subjects undergoing autopsy at a large medical c...

journal_title：Archives of pathology & laboratory medicine

authors： Haque AK,Gadre S,Taylor J,Haque SA,Freeman D,Duarte A

更新日期：2008-09-01 00:00:00

abstract：:Glomus tumor is a benign mesenchymal neoplasm comprising less than 2% of soft tissue tumors. It is composed of cells resembling modified smooth muscle cells of the normal glomus body. The glomus body, a thermoregulator, is a specialized form of arteriovenous anastomosis localized in dermal and precoccygeal soft tissue...

journal_title：Archives of pathology & laboratory medicine

authors： Gombos Z,Zhang PJ

更新日期：2008-09-01 00:00:00

abstract：CONTEXT:Most gastric gastrointestinal stromal tumors (GISTs) express CD117/c-kit, as do a subset of metastatic melanomas, leading to a diagnostic dilemma in some cases. OBJECTIVE:To further differentiate GISTs from melanoma, we investigated expression of melanoma markers in GISTs using a well-characterized set of gast...

journal_title：Archives of pathology & laboratory medicine

authors： Guler ML,Daniels JA,Abraham SC,Montgomery EA

更新日期：2008-08-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma with a poor prognosis that may be confused with less aggressive diseases, such as small lymphocytic lymphoma and follicular lymphoma. In many cases immunophenotyping, particularly analysis of reactivity for CD5 and CD10, is an important adjunct to morphology that us...

journal_title：Archives of pathology & laboratory medicine

authors： Sriganeshan V,Blom TR,Weissmann DJ

更新日期：2008-08-01 00:00:00

abstract：CONTEXT:Deletion of the short arm of chromosome 3 (3p deletion) is a cytogenetic abnormality generally associated with clear cell renal cell carcinoma, the most aggressive form of renal epithelial tumor. OBJECTIVE:To cytogenetically characterize 24 renal tumors in order to check the incidence and the type of 3p deleti...

journal_title：Archives of pathology & laboratory medicine

authors： Gayrard N,Cacheux V,Iborra F,Mourad G,Argilés A

更新日期：2008-06-01 00:00:00

abstract：CONTEXT:The immunophenotypic profile of basophils is not yet fully established, and the immunophenotypic changes in chronic myelogenous leukemia are not fully characterized. OBJECTIVE:To establish a comprehensive immunophenotypic spectrum of normal basophils and to assess the range of immunophenotypic aberrations of b...

journal_title：Archives of pathology & laboratory medicine

authors： Han X,Jorgensen JL,Brahmandam A,Schlette E,Huh YO,Shi Y,Awagu S,Chen W

更新日期：2008-05-01 00:00:00

abstract：:Examination of the bone marrow poses several unique challenges to the pathologist: it is a semisolid organ without helpful gross correlation, it exists in a dynamic state with the peripheral blood and other organs of the lymphohemopoietic system, and the diagnosis of diseases affecting bone marrow often depends heavil...

journal_title：Archives of pathology & laboratory medicine

authors： Hasserjian RP

更新日期：2008-04-01 00:00:00

abstract：CONTEXT:Newborns are often screened prior to discharge for hyperbilirubinemia. Transcutaneous bilirubin analyzers, such as the BiliChek, are promoted as screening tools, but it is unclear whether they also function well as monitoring devices. Newborns on home phototherapy require frequent determinations of serum biliru...

journal_title：Archives of pathology & laboratory medicine

authors： Reyes CA,Stednitz DR,Hahn C,Mutchie KD,McCullough SR,Kronberg K

更新日期：2008-04-01 00:00:00

abstract：CONTEXT:The uses of monoclonal antibodies via immunochemistry have been reported frequently within the literature using various methodologies with applications to cytology specimens. The direct application of immunochemistry to cytology may have a variety of pitfalls that the general pathologist familiar with its appli...

journal_title：Archives of pathology & laboratory medicine

authors： Fowler LJ,Lachar WA

更新日期：2008-03-01 00:00:00

abstract：CONTEXT:As we write, novel antibodies that may well alter the routine practice of surgical neuropathology are in development, characterization, and the early stages of clinical use. These will be used for purposes of tumor subclassification, as prognostic markers, as identifiers of potential therapeutic targets, and as...

journal_title：Archives of pathology & laboratory medicine

authors： Edgar MA,Rosenblum MK

更新日期：2008-03-01 00:00:00

abstract：:The purpose of this review is to address some common problems involving the diagnosis of trophoblastic lesions. ...

journal_title：Archives of pathology & laboratory medicine

authors： Deavers MT,Kalhor N,Silva EG

更新日期：2008-02-01 00:00:00

abstract：CONTEXT:Previous studies have shown that paraproteins caused spurious results on individual analytes including total bilirubin (TBIL), direct bilirubin (DBIL), or HDL-cholesterol (HDL-C). Studies demonstrating paraprotein interferences with multiple analytes measured by different analyzers have not been reported. OBJE...

journal_title：Archives of pathology & laboratory medicine

authors： Yang Y,Howanitz PJ,Howanitz JH,Gorfajn H,Wong K

更新日期：2008-02-01 00:00:00

abstract：:The salivary glands, despite their relatively simple morphology, give rise to more than 30 histologically distinct benign and malignant tumors. Salivary gland neoplasms comprise less than 2% of all tumors in humans and 3% of all head and neck tumors. They arise in the parotid gland in 80% of cases, and approximately 8...

journal_title：Archives of pathology & laboratory medicine

authors： Schneider M,Rizzardi C

更新日期：2008-02-01 00:00:00

abstract：:Typical cerebellar or spinal cord hemangioblastoma is often solitary and has a benign clinical course, whereas disseminated hemangioblastomatosis is extremely rare. We report a 75-year-old man with disseminated "leptomeningeal" hemangioblastomatosis and concurrent paraneoplastic limbic encephalitis who died of this di...

journal_title：Archives of pathology & laboratory medicine

authors： Ramachandran R,Lee HS,Matthews B,Shatzel A,Tihan T

更新日期：2008-01-01 00:00:00

abstract：CONTEXT:The correlation of the diagnosis made at intraoperative consultation (IC) with the final diagnosis is one of the cornerstones of quality assurance in the anatomic pathology laboratory. OBJECTIVE:To review correlation of IC diagnoses with final diagnoses during a 1-year period in a regionalized, multisite hospi...

journal_title：Archives of pathology & laboratory medicine

authors： White VA,Trotter MJ

更新日期：2008-01-01 00:00:00

abstract：CONTEXT:Eighty-two million surgical pathology and cytology reports were issued in the United States during 2007; a subset of these reports will be misunderstood by readers. Recent attention has focused on standardizing the content of pathology reports, particularly for common malignancies, to facilitate transmission of...

journal_title：Archives of pathology & laboratory medicine

authors： Valenstein PN

更新日期：2008-01-01 00:00:00

abstract：CONTEXT:Molecular diagnostic applications that use microarrays to analyze large numbers of genes simultaneously require high-quality mRNA. As these genome-wide expression assays become more commonly used in medical practice, pathologists and oncologists will benefit from understanding the importance of obtaining high-q...

journal_title：Archives of pathology & laboratory medicine

authors： Medeiros F,Rigl CT,Anderson GG,Becker SH,Halling KC

更新日期：2007-12-01 00:00:00

abstract：CONTEXT:Cytologic examination of the respiratory tract has been a useful diagnostic tool when evaluating neoplastic lesions of the respiratory tract. However, we have limited experience in the application of this technique in the management of nonneoplastic occupational and environmental diseases of the lung and pleura...

journal_title：Archives of pathology & laboratory medicine

authors： Laucirica R,Ostrowski ML

更新日期：2007-11-01 00:00:00

abstract：CONTEXT:The differential diagnosis of eosinophilic renal tumors can be difficult by light microscopy. In particular, chromophobe renal cell carcinoma (RCC) is difficult to distinguish from oncocytoma. This differential diagnosis is important because chromophobe RCC is malignant, whereas oncocytoma is benign. Furthermor...

journal_title：Archives of pathology & laboratory medicine

authors： Hornsby CD,Cohen C,Amin MB,Picken MM,Lawson D,Yin-Goen Q,Young AN

更新日期：2007-10-01 00:00:00

abstract：:Canalicular adenomas are benign neoplasms that arise from salivary glands and often present as painless enlarging nodules. They have a predilection for upper lip but can be found throughout the oropharynx. To our knowledge, canalicular adenoma arising in the esophagus has never been described in the English literature...

journal_title：Archives of pathology & laboratory medicine

authors： Grimm EE,Rulyak SJ,Sekijima JH,Yeh MM

更新日期：2007-10-01 00:00:00

abstract：CONTEXT:Mutations of the proto-oncogene B-raf (BRAF) have been detected in melanocytic lesions and papillary carcinomas of the thyroid, and identification of these mutations could be useful in resolving some diagnostic problems. OBJECTIVE:To develop a method to evaluate mutations of BRAF that could provide results muc...

journal_title：Archives of pathology & laboratory medicine

authors： Hay R,MacRae E,Barber D,Khalil M,Demetrick DJ

更新日期：2007-09-01 00:00:00

abstract：CONTEXT:The endomyocardial biopsy is the mainstay for monitoring acute allograft rejection in heart transplantation. Objective and accurate assessment of cellular and humoral types of rejection is important to optimize immunosuppressive therapy, avoid therapeutic complications, and improve patient outcome. The grading ...

journal_title：Archives of pathology & laboratory medicine

authors： Tan CD,Baldwin WM 3rd,Rodriguez ER

更新日期：2007-08-01 00:00:00

abstract：CONTEXT:Although the early post-myelosuppressive chemotherapy pathologic changes of the marrow have been described, the rate and the histologic definition of recovery are not defined. OBJECTIVE:To study the rate of recovery of bone marrow in patients given myelosuppressive therapy for acute myelogenous leukemia, estab...

journal_title：Archives of pathology & laboratory medicine

authors： Khalil F,Cualing H,Cogburn J,Miles L

更新日期：2007-08-01 00:00:00

abstract：CONTEXT:In immunohistochemistry, nonstandardized antigen retrieval protocols and fluids, poor-quality antibodies, and the presence of endogenous biotin frequently lead to incorrect results. Recently, advanced reagents including bifunctional SkipDewax pretreatment solution (BSPS), rabbit monoclonal (RM) antibodies, and ...

journal_title：Archives of pathology & laboratory medicine

authors： Wong SC,Chan JK,Lo ES,Chan AK,Wong MC,Chan CM,Lam MY,Chan AT

更新日期：2007-07-01 00:00:00